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Effectiveness of nanoparticle-bound ampicillin in the treatment of Listeria monocytogenes infection in athymic nude mice
- Source :
- Antimicrobial agents and chemotherapy. 32(8)
- Publication Year :
- 1988
-
Abstract
- The effectiveness of nanoparticle-bound ampicillin was tested in the treatment of experimental Listeria monocytogenes infection in congenitally athymic nude mice. Nanoparticles of polyisohexylcyanoacrylate (PIHCA) 187 +/- 13 nm in diameter were bound to ampicillin at an ampicillin/PIHCA ratio of 0.2:1. The proportion of ampicillin bound was 90% +/- 3%. After adsorption onto nanoparticles, the therapeutic activity of ampicillin increased dramatically over that in the free state. Thus, 2.4 mg of nanoparticle-bound ampicillin (three doses of 0.8 mg each) had a greater therapeutic effect than 48 mg of free ampicillin (three doses of 16 mg each). These results might provide an incentive for further development of intracellular targeting of antibiotics on biodegradable polymeric carriers.
- Subjects :
- medicine.drug_class
Ratón
medicine.medical_treatment
Antibiotics
Colony Count, Microbial
Mice, Nude
Spleen
medicine.disease_cause
Dosage form
Microbiology
Mice
Listeria monocytogenes
Ampicillin
medicine
Animals
Pharmacology (medical)
Listeriosis
Cyanoacrylates
Pharmacology
Chemotherapy
Drug Carriers
business.industry
biochemical phenomena, metabolism, and nutrition
Mice, Inbred C57BL
Infectious Diseases
medicine.anatomical_structure
Liver
business
Drug carrier
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 00664804
- Volume :
- 32
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....fc4e04c7b4d6511e16aaac484cbf9de1