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Identifying Plasma Biomarkers with high specificity for major depressive disorder: A multi-level proteomics study
- Source :
- Journal of Affective Disorders, 277, 620-630. Elsevier B.V.
- Publication Year :
- 2020
-
Abstract
- Background There are currently no objective diagnostic biomarkers for major depressive disorder (MDD) due to the biological complexity of the disorder. The existence of blood-based biomarkers with high specificity would be convenient for the clinical diagnosis of MDD. Methods A comprehensive plasma proteomic analysis was conducted in a highly homogeneous cohort [7 drug-naive MDD patients and 7 healthy controls (HCs)], with bioinformatics analysis combined with machine learning used to screen candidate proteins. Verification of reproducibility and specificity was conducted in independent cohorts [60 HCs and 74 MDD, 42 schizophrenia (SZ) and 39 bipolar I disorder (BD-I) drug-naive patients]. Furthermore, verification of consistency was accomplished by proteomic analysis of postmortem brain tissue from 16 MDD patients and 16 HCs. Results: Levels of C-reactive protein (CRP), antithrombin III (ATIII), inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and vitamin D-binding protein (VDB) were significantly higher in MDD patients, both in the discovery cohort and independent replication cohort. In comparison with SZ or BD-I patients, two proteins (VDB and ITIH4) were significantly elevated only in MDD patients. In addition, increased VDB and ITIH4 were observed consistently in both plasma and postmortem dorsolateral prefrontal cortex tissues of MDD patients. Furthermore, a panel consisting of all four plasma proteins was able to distinguish MDD patients from HCs or SZ or BD-I patients with the highest accuracy. Conclusion Plasma ITIH4 and VDB may be potential plasma biomarkers of MDD with high specificity. The four-protein panel is more suitable as a potential clinical diagnostic marker for MDD.
- Subjects :
- Oncology
Proteomics
medicine.medical_specialty
Bipolar I disorder
Vitamin D-binding protein
behavioral disciplines and activities
03 medical and health sciences
Plasma
0302 clinical medicine
Internal medicine
mental disorders
medicine
Humans
Depressive Disorder, Major
business.industry
Reproducibility of Results
medicine.disease
Blood proteins
030227 psychiatry
Dorsolateral prefrontal cortex
Psychiatry and Mental health
Clinical Psychology
medicine.anatomical_structure
Pharmaceutical Preparations
Schizophrenia
Cohort
Major depressive disorder
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 15732517 and 01650327
- Volume :
- 277
- Database :
- OpenAIRE
- Journal :
- Journal of affective disorders
- Accession number :
- edsair.doi.dedup.....fc3543099b67f768c4a7865e1c730125