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Frequency-Dependent Dynamics of Functional Connectivity Networks During Seizure Termination in Childhood Absence Epilepsy: A Magnetoencephalography Study
- Source :
- Frontiers in Neurology, Vol 12 (2021), Frontiers in Neurology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Objective: Our aim was to investigate the dynamics of functional connectivity (FC) networks during seizure termination in patients with childhood absence epilepsy (CAE) using magnetoencephalography (MEG) and graph theory (GT) analysis.Methods: MEG data were recorded from 22 drug-naïve patients diagnosed with CAE. FC analysis was performed to evaluate the FC networks in seven frequency bands of the MEG data. GT analysis was used to assess the topological properties of FC networks in different frequency bands.Results: The patterns of FC networks involving the frontal cortex were altered significantly during seizure termination compared with those during the ictal period. Changes in the topological parameters of FC networks were observed in specific frequency bands during seizure termination compared with those in the ictal period. In addition, the connectivity strength at 250–500 Hz during the ictal period was negatively correlated with seizure frequency.Conclusions: FC networks associated with the frontal cortex were involved in the termination of absence seizures. The topological properties of FC networks in different frequency bands could be used as new biomarkers to characterize the dynamics of FC networks related to seizure termination.
- Subjects :
- magnetoencephalography
Frontal cortex
genetic structures
Biology
behavioral disciplines and activities
Childhood absence epilepsy
medicine
Ictal
In patient
RC346-429
Original Research
Seizure frequency
medicine.diagnostic_test
multifrequency
Functional connectivity
functional connectivity
Magnetoencephalography
medicine.disease
nervous system
Neurology
childhood absence epilepsy
Neurology (clinical)
Neurology. Diseases of the nervous system
Neuroscience
psychological phenomena and processes
seizure termination
Subjects
Details
- Language :
- English
- ISSN :
- 16642295
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....fc2bc1c516059599dc5a7152f20c4d50