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Risk of myocardial infarction associated with non-steroidal anti-inflammatory drugs: Impact of additional confounding control for variables collected from self-reported data
- Source :
- Journal of Clinical Pharmacy and Therapeutics, Journal of Clinical Pharmacy and Therapeutics, 44(4), 623. Blackwell Publishing Ltd
- Publication Year :
- 2018
-
Abstract
- Summary What is known and objective Important risk factors and over‐the‐counter (OTC) dispensing of non‐steroidal anti‐inflammatory drugs (NSAIDs) are often not routinely recorded in electronic health records. This study aimed to assess the impact of patient's reports on these factors on the risk of acute myocardial infarction (AMI) for NSAID use. Methods A nested case‐control study was conducted among adults in the Utrecht Cardiovascular Pharmacogenetics study. Cases were patients with a first diagnosis of AMI as a hospital discharge diagnosis and controls were those without AMI. NSAID exposure was either current use of selective COX‐2 inhibitors or conventional NSAIDs. Information was collected from The Dutch PHARMO Database Network (pharmacy records of drug dispensing linked to hospitalization records) and the patient's questionnaire (lifestyle factors, body mass index and history of cardiovascular diseases). Unconditional logistic regression analysis was used to calculate odds ratios (ORs) and to control for confounding factors. Results We identified 970 AMI cases and 2974 controls. Among cases, 11 (1.1%) and 185 (19.1%) were exposed to selective COX‐2 inhibitors and conventional NSAIDs, respectively. Compared to non‐use, none of these drug classes were associated with an increased risk of AMI (adjusted OR 1.07, 95% CI: 0.52‐2.18 and 0.93, 95% CI: 0.77‐1.12, respectively). Additional adjustment for potential confounders from patient's reports did not change the risk estimates (adjusted OR 1.08, 95% CI: 0.53‐2.22 and 0.89, 95% CI: 0.73‐1.09, respectively). What is new and conclusion Additional confounding control for variables from self‐reported data or considering self‐reported OTC NSAID use did not change the risk estimates for the association between NSAIDs and AMI.
- Subjects :
- Male
pharmacoepidemiology
endogenous compound
Utrecht cardiovascular pharmacogenetics study
Myocardial Infarction
cyclooxygenase 2 inhibitor
Logistic regression
030226 pharmacology & pharmacy
0302 clinical medicine
Risk Factors
nonsteroid antiinflammatory agent
Medicine
Pharmacology (medical)
selective COX-2 inhibitors
030212 general & internal medicine
pharmacogenetics
adult
Confounding
Anti-Inflammatory Agents, Non-Steroidal
article
risk assessment
Pharmacoepidemiology
Middle Aged
Hospitalization
patient’s reports
Female
Original Article
Risk assessment
lifestyle
medicine.medical_specialty
side effect
adverse drug reaction
acute myocardial infarction
03 medical and health sciences
Internal medicine
Humans
controlled study
human
Pharmacology
Cyclooxygenase 2 Inhibitors
business.industry
questionnaire
Case-control study
Odds ratio
Original Articles
case control study
medicine.disease
major clinical study
body mass
non prescription drug
hospital discharge
acute heart infarction
Case-Control Studies
conventional NSAIDs
Self Report
business
Body mass index
pharmacy records
Adverse drug reaction
selective COX‐2 inhibitors
Subjects
Details
- ISSN :
- 13652710 and 02694727
- Volume :
- 44
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of clinical pharmacy and therapeutics
- Accession number :
- edsair.doi.dedup.....fc24f8705c060e1dc1ac0dc85785a339