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An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line
- Source :
- Analytical Cellular Pathology (Amsterdam), Analytical Cellular Pathology, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi, 2021.
-
Abstract
- One of the most important class of natural compounds with successful preclinical results in the management of cancer is the flavonoids. Due to the plethora of biological activities, apigenin (4 ′ ,5,7 trihydroxyflavone) is a main representant of the flavone subclass. Although the antiproliferative and antiangiogenic effects of apigenin were studied on a significant number of human and murine melanoma cell lines, in order to complete the data existing in the literature, the aim of this study is to evaluate the in vitro effect of apigenin on SK-MEL-24 human melanoma cell line as well as in vivo on tumor angiogenesis using the aforementioned cell line on the chorioallantoic membrane assay. Results have shown that in the range of tested doses, the phytocompound presents significant antiproliferative, cytotoxic, and antimigratory potential at 30 μM, respectively, 60 μM. Moreover, the phytocompound in both tested concentrations limited melanoma cell growth and migration and induced a reduced angiogenic reaction limiting melanoma cell development.
- Subjects :
- 0301 basic medicine
Cancer Research
Article Subject
Angiogenesis Inhibitors
Pathology and Forensic Medicine
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
In vivo
Cell Line, Tumor
medicine
Cytotoxic T cell
Animals
Humans
Apigenin
Melanoma
RC254-282
Cell Proliferation
QH573-671
Cell growth
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cell Biology
General Medicine
medicine.disease
In vitro
Chorioallantoic membrane
030104 developmental biology
chemistry
Cell culture
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Cytology
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 22107177
- Database :
- OpenAIRE
- Journal :
- Analytical Cellular Pathology
- Accession number :
- edsair.doi.dedup.....fc15ff82c06da256c3113e651de9c419
- Full Text :
- https://doi.org/10.1155/2021/5552664