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Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus
Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus
- Publication Year :
- 2019
- Publisher :
- Springer International Publishing, 2019.
-
Abstract
- Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. 387 HD patients from 18 dialysis centers in Italy. Associations of DM, levels of BGP, vitamin D and VC were evaluated. Time-to-event analysis for all-cause mortality was performed by the Kaplan–Meier. Patients with DM had lower levels of total BGP (139.00 vs. 202.50 mcg/L, p
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Vitamin K
Bone disease
medicine.medical_treatment
Osteocalcin
030232 urology & nephrology
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Gastroenterology
Diabetes Complications
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Renal Dialysis
Risk Factors
Internal medicine
medicine
Vitamin D and neurology
Humans
Renal Insufficiency, Chronic
Vitamin D
Vascular Calcification
BGP
Hemodialysis
Dialysis
Aged
Proportional Hazards Models
biology
business.industry
Warfarin
Middle Aged
medicine.disease
Italy
biology.protein
Spinal Fractures
Female
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fc141f2ad3a8483e42232a99af8d81ce