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Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus

Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus

Authors :
Sandro Giannini
Andrea Aghi
Maria Fusaro
Stefania Sella
Maria Antonietta Rizzo
Luca Di Lullo
Maura Ravera
Antonio Piccoli
Annalisa Pitino
Fabrizio Fabris
Davide Gatti
Maurizio Gallieni
Thomas L. Nickolas
Mario Plebani
Maurizio Rossini
Giuliano Brunori
Giorgio Iervasi
Graziella D'Arrigo
Maria Cristina Mereu
Andrea Giusti
Antonio Bellasi
Giovanni Tripepi
Publication Year :
2019
Publisher :
Springer International Publishing, 2019.

Abstract

Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. 387 HD patients from 18 dialysis centers in Italy. Associations of DM, levels of BGP, vitamin D and VC were evaluated. Time-to-event analysis for all-cause mortality was performed by the Kaplan–Meier. Patients with DM had lower levels of total BGP (139.00 vs. 202.50 mcg/L, p

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....fc141f2ad3a8483e42232a99af8d81ce