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Mechanisms behind the polarized distribution of lipids in epithelial cells
- Source :
- Biochimica et Biophysica Acta (BBA) - Biomembranes. 1862:183145
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Epithelial cells are polarized cells and typically display distinct plasma membrane domains: basal plasma membrane domains face the underlying tissue, lateral domains contact adjacent cells and apical domains face the exterior lumen. Each membrane domain is endowed with a specific macromolecular composition that constitutes the functional identity of that domain. Defects in apical-basal plasma membrane polarity altogether or more subtle defects in the composition of either apical or basal plasma membrane domain can give rise to severe diseases. Lipids are the main component of cellular membranes and mechanisms that control their polarized distribution in epithelial cells are emerging. In particular sphingolipids and phosphatidylinositol lipids have taken center stage in the organization of the apical and basolateral plasma membrane domain. This short review article discusses mechanisms that contribute to the polarized distribution of lipids in epithelial cells.
- Subjects :
- DOMAINS
Biophysics
TIGHT JUNCTIONS
Endosomes
Phosphatidylinositols
Biochemistry
PATHWAY
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell polarity
Animals
Humans
TRAFFICKING
Phosphatidylinositol
030304 developmental biology
0303 health sciences
Tight junction
CHOLESTEROL
MICROVILLUS INCLUSION DISEASE
Cell Polarity
LOCALIZATION
Epithelial Cells
PHOSPHOINOSITIDES
Cell Biology
Basolateral plasma membrane
Sphingolipid
DIFFUSION
Basal plasma membrane
Membrane
chemistry
PLASMA-MEMBRANE
030217 neurology & neurosurgery
Lumen (unit)
Subjects
Details
- ISSN :
- 00052736
- Volume :
- 1862
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Accession number :
- edsair.doi.dedup.....fc0adef7d578e59244a5812db54a3fe8