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Helicobacter pylori infection in children: Nutritional status and associations with serum Leptin, Ghrelin, and IGF-1 levels
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Background Helicobacter pylori is associated with gastrointestinal diseases such as gastritis, peptic ulcers, malignancy and lymphoma, and extra-gastrointestinal conditions. H. pylori infection is negatively associated with children's growth. Chronic inflammation of the stomach that results in the loss of appetite and, dysregulation of neuroendocrine hormones such as leptin, and ghrelin are the probable reasons of this negative association. The objective of this study is to determine the serum levels of leptin, ghrelin, and IGF-1 in H. pylori-infected children and their relations with growth. Materials and methods A hundred and sixty-one school children aged between 6 and 14 years were selected randomly from five primary schools representing a cross section of population. Demographic and sociocultural characteristics, and anthropometric measurements were recorded. Serum H. pylori IgG, insulin-like growth factor-1, leptin, and ghrelin levels were measured in all children. The children were grouped according to the nutritional status and Helicobacter pylori seropositivity. Nutritional indices were compared among groups in association with serum leptin, ghrelin, and insulin-like growth factor-1 levels. Results H. pylori IgG positivity was found in 34.2%, and 14.9% of children were malnourished. H. pylori seropositivity was significantly higher in older ages (10.32 ± 2.26 vs 9.53 ± 2.36 years, p = .036), and body weight and height Z scores were significantly lower in H. pylori-seropositive children (−0.33 ± 1.08 vs 0.04 ± 1.26, p = .044 and 0.13 ± 0.92 vs 0.23 ± 0.91, p = .018 respectively). H. pylori seropositivity was found to be an independent risk factor for shorter body height (p = .01). Serum leptin, ghrelin, and IGF-1 levels were not associated with H. pylori IgG seropositivity (0.35 vs 0.55 ng/mL, p = .3; 3267.4 ± 753.0 vs 2808.3 ± 911.4 pg/mL, p = .06; 470 ± 176 vs 521 ± 179 ng/mL, p = .32, respectively). Conclusions Children infected with H. pylori are prone to short stature. This effect seems to be independent of neuroendocrine hormones.
- Subjects :
- Serum
Leptin
Male
Epidemiology
Growth
Growth-factor
Adolescents
Gastroenterology
Peptic-ulceration
0302 clinical medicine
Nutritional status
Antibody blood level
030212 general & internal medicine
Pylori
Insulin-Like Growth Factor I
Child
media_common
Priority journal
education.field_of_study
Schools
biology
Anthropometry
Stomach
General Medicine
H
Ghrelin
Risk-factors
Infectious Diseases
medicine.anatomical_structure
Gastritis
030211 gastroenterology & hepatology
Female
medicine.symptom
Age distribution
Human
medicine.medical_specialty
Adolescent
media_common.quotation_subject
Population
Body-mass index
Major clinical study
Microbiology
Article
Helicobacter Infections
Helicobacter infection
03 medical and health sciences
Internal medicine
medicine
Humans
Risk factor
education
Students
Demography
Helicobacter pylori
business.industry
Malnutrition
Appetite
Body weight
biology.organism_classification
Somatomedin C
Childhood
Helicobacter Pylori
Duodenum Ulcer
Body height
Short stature
Endocrinology
Cross-Sectional Studies
Immunoglobulin G antibody
business
Hormone blood level
Gastroenterology & hepatology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fc05eeec6bf5317af222017025489877