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Ophthalmic Glucose Monitoring Using Disposable Contact Lenses—A Review
- Source :
- Journal of Fluorescence. 14:617-633
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- We have developed a range of disposable and colorless tear glucose sensing contact lenses, using off-the-shelf lenses embedded with new water soluble, highly fluorescent and glucose sensitive boronic acid containing fluorophores. The new lenses are readily able to track tear glucose levels and therefore blood glucose levels, which are ideally suited for potential use by diabetics. The fluorescence responses from the lenses can be monitored using simple excitation and emission detection devices. The novelty of our approach is two fold. Firstly, the notion of sensing extremely low glucose concentrations in tears, which track blood levels, by our contact lens approach, and secondly, the unique compatibility of our new glucose signaling probes with the internal mildly acidic contact lens environment. The new lenses are therefore ideal for the non-invasive and continuous monitoring of tear glucose, with about 15-min response time, and a measured shelf life in excess of 3 months. In this review article, we show that fluorescence based signaling using plastic disposable lenses, which have already been industrially optimized with regard to vision correction and oxygen/analyte permeability etc, may a notable alternative to invasive and random finger pricking, the most widely used glucose monitoring technology by diabetics.
- Subjects :
- Anions
Analyte
Sociology and Political Science
Contact Lenses
Clinical Biochemistry
Analytical chemistry
Glucose sensing
Fructose
Biochemistry
Glucose signaling
Article
Fluorescence spectroscopy
Low glucose
Halogens
Humans
Fluorometry
Spectroscopy
Fluorescent Dyes
Monitoring, Physiologic
Glucose sensitivity
Chemistry
Quinolinium Compounds
Hydrogen-Ion Concentration
Boronic Acids
eye diseases
Contact lens
Clinical Psychology
Glucose
Spectrometry, Fluorescence
Water soluble
Spectrophotometry
Tears
sense organs
Law
Algorithms
Social Sciences (miscellaneous)
Biomedical engineering
Subjects
Details
- ISSN :
- 10530509
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Fluorescence
- Accession number :
- edsair.doi.dedup.....fc05ade254282f7f485ca6bb9c205ea4