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WHO ‘Treatment as Prevention’ guidelines are unlikely to decrease HIV transmission in the UK unless undiagnosed HIV infections are reduced
- Source :
- AIDS. 28:281-283
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- The WHO guidelines recommend antiretroviral therapy (ART) begins when CD4 cell counts reach less than 500 cells to reduce HIV transmission. In the UK, 96 000 people were living with HIV (PLWHIV) in 2011, ART coverage was 84% among the diagnosed population and 42% of PLWHIV had detectable viraemia. Using published methods, we estimate starting ART at below 500 CD4 cells could have reduced the proportion of PLWHIV with detectable viraemia from 42% to 38%, whereas halving the undiagnosed population could have led to a decrease to 28%. In the UK, it is unlikely early treatment will reduce HIV transmission unless the undiagnosed population is substantially reduced.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Immunology
Population
Human immunodeficiency virus (HIV)
HIV Infections
World Health Organization
medicine.disease_cause
Chemoprevention
Disease Transmission, Infectious
medicine
Humans
Immunology and Allergy
Cd4 cell count
education
Hiv transmission
Health policy
education.field_of_study
business.industry
Health Policy
virus diseases
Viral Load
Treatment as prevention
Virology
United Kingdom
Infectious Diseases
Anti-Retroviral Agents
Who guidelines
Female
business
Viral load
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....fbfa67eecf7a7d7df19c04f44202d38a