PML in a patient with myasthenia gravis treated with multiple immunosuppressing agents

Progressive multifocal leukoencephalopathy (PML) is an often fatal opportunistic infection of the JC virus resulting in demyelination of the CNS. PML is well-described in patients with multiple sclerosis (MS) exposed to natalizumab. PML is rare in patients with myasthenia gravis (MG) and is also rare following rituximab exposure. We report PML in a patient with MG after immunosuppression that includes rituximab.