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Low-Dimensional Assemblies of Magnetic MnFe 2 O 4 Nanoparticles and Direct In Vitro Measurements of Enhanced Heating Driven by Dipolar Interactions: Implications for Magnetic Hyperthermia
- Source :
- ACS Applied Nano Materials, Zaguán. Repositorio Digital de la Universidad de Zaragoza, instname, CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Publication Year :
- 2020
-
Abstract
- Magnetic fluid hyperthermia (MFH), the procedure of raising the temperature of tumor cells using magnetic nanoparticles (MNPs) as heating agents, has proven successful in treating some types of cancer. However, the low heating power generated under physiological conditions makes necessary a high local concentration of MNPs at tumor sites. Here, we report how the in vitro heating power of magnetically soft MnFe$_2$O$_4$ nanoparticles can be enhanced by intracellular low-dimensional clusters through a strategy that includes: a) the design of the MNPs to retain N\'eel magnetic relaxation in high viscosity media, and b) culturing MNP-loaded cells under magnetic fields to produce elongated intracellular agglomerates. Our direct in vitro measurements demonstrated that the specific loss power (SLP) of elongated agglomerates ($SLP=576\pm33$ W/g) induced by culturing BV2 cells in situ under a dc magnetic field was increased by a factor of 2 compared to the $SLP=305\pm25$ W/g measured in aggregates freely formed within cells. A numerical mean-field model that included dipolar interactions quantitatively reproduced the SLPs of these clusters both in phantoms and in vitro, suggesting that it captures the relevant mechanisms behind power losses under high-viscosity conditions. These results indicate that in situ assembling of MNPs into low-dimensional structures is a sound possible way to improve the heating performance in MFH.<br />Comment: 63 pages, 19 figures
- Subjects :
- In situ
Materials science
MAGNETIC FLUID HYPERTHERMIA
Nanoparticle
FOS: Physical sciences
02 engineering and technology
Condensed Matter - Soft Condensed Matter
010402 general chemistry
01 natural sciences
purl.org/becyt/ford/1 [https]
General Materials Science
Physics - Biological Physics
MAGNETIC NANOPARTICLES
SPECIFIC LOSS POWER
purl.org/becyt/ford/1.3 [https]
021001 nanoscience & nanotechnology
equipment and supplies
In vitro
0104 chemical sciences
3. Good health
Magnetic field
Dipole
Magnetic hyperthermia
Chemical engineering
Agglomerate
Biological Physics (physics.bio-ph)
IN-FIELD CELL CULTURE
LINEAR AGGREGATES
MAGNETIC ANISOTROPY
Magnetic nanoparticles
Soft Condensed Matter (cond-mat.soft)
0210 nano-technology
Subjects
Details
- ISSN :
- 25740970
- Database :
- OpenAIRE
- Journal :
- ACS Applied Nano Materials
- Accession number :
- edsair.doi.dedup.....fbd63b444f2367437cddfddea5a1fdfc
- Full Text :
- https://doi.org/10.1021/acsanm.0c01545