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Decreased density of amygdaloid parvalbumin-positive interneurons and behavioral changes in dystonic hamsters (Mesocricetus auratus)
- Source :
- Behavioral neuroscience. 122(1)
- Publication Year :
- 2008
-
Abstract
- The dtsz hamster represents a model of primary paroxysmal nonkinesiogenic dyskinesia in which dystonic episodes can be induced by stress and anxious stimuli. This disease is regarded as a basal ganglia disorder. In fact, a deficit of striatal interneurons could play a key role in the pathophysiology in dystonic hamsters. Because the involvement of limbic structures cannot be excluded so far, the density of parvalbumin-immunoreactive (PV+) interneurons was determined in the basolateral amygdala in the present study. Compared with nondystonic hamsters, the density of PV+ interneurons was moderately decreased in the dtsz mutant. The functional consequence of this finding was examined by behavioral analyses. Examinations in the elevated plus maze and in a modified open field failed to disclose an enhanced anxiety-related behavior in dtsz hamsters (Mesocricetus auratus). A lower acoustic startle response and a stronger habituation in mutant hamsters than in controls correlated with a decreased body weight. Interestingly, prepulse inhibition was absent in mutant hamsters. The latter finding suggests a disturbed sensorimotor gating that can be related to alterations in both the basal ganglia nuclei and in limbic structures.
- Subjects :
- Male
Reflex, Startle
Hamster
Amygdala
Behavioral Neuroscience
Limbic system
Interneurons
Cricetinae
medicine
Animals
Habituation, Psychophysiologic
Maze Learning
Prepulse inhibition
Analysis of Variance
biology
Behavior, Animal
Mesocricetus
Age Factors
Neural Inhibition
biology.organism_classification
Startle reaction
Disease Models, Animal
Dystonia
medicine.anatomical_structure
Parvalbumins
nervous system
Acoustic Stimulation
biology.protein
Exploratory Behavior
Female
Psychology
Neuroscience
Parvalbumin
Basolateral amygdala
Subjects
Details
- ISSN :
- 07357044
- Volume :
- 122
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Behavioral neuroscience
- Accession number :
- edsair.doi.dedup.....fbd4c79d04ddb3e01fa2cf672eb7713e