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Astrovirus Induces Diarrhea in the Absence of Inflammation and Cell Death
- Source :
- Journal of Virology
- Publication Year :
- 2003
- Publisher :
- American Society for Microbiology, 2003.
-
Abstract
- Astroviruses are a leading cause of infantile viral gastroenteritis worldwide. Very little is known about the mechanisms of astrovirus-induced diarrhea. One reason for this is the lack of a small-animal model. Recently, we isolated a novel strain of astrovirus (TAstV-2) from turkeys with the emerging infectious disease poult enteritis mortality syndrome. In the present studies, we demonstrate that TAstV-2 causes growth depression, decreased thymus size, and enteric infection in infected turkeys. Infectious TAstV-2 can be recovered from multiple tissues, including the blood, suggesting that there is a viremic stage during infection. In spite of the severe diarrhea, histopathologic changes in the intestine were mild and there was a surprising lack of inflammation. This may be due to the increased activation of the potent immunosuppressive cytokine transforming growth factor beta during astrovirus infection. These studies suggest that the turkey will be a useful small-animal model with which to study astrovirus pathogenesis and immunity.
- Subjects :
- Diarrhea
Male
Turkeys
Poult Enteritis Mortality Syndrome
viruses
medicine.medical_treatment
Immunology
Inflammation
Biology
Microbiology
Cell Line
Astrovirus
Pathogenesis
Transforming Growth Factor beta
Immunity
Astroviridae Infections
Virology
medicine
Animals
Humans
Poultry Diseases
Cell Death
virus diseases
biology.organism_classification
Cytokine
Insect Science
Emerging infectious disease
Pathogenesis and Immunity
Female
medicine.symptom
Mamastrovirus
Subjects
Details
- ISSN :
- 0022538X
- Volume :
- 77
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....fbc4847658b1e8e09b18842d69c65b0a
- Full Text :
- https://doi.org/10.1128/jvi.77.21.11798-11808.2003