Back to Search
Start Over
Common skeletal growth retardation disorders resulting from abnormalities within the mesenchymal stem cells reservoirs in the epiphyseal organs pertaining to the long bones
- Source :
- Journal of pediatric endocrinologymetabolism : JPEM. 23(11)
- Publication Year :
- 2011
-
Abstract
- Among the objectives in writing the current chapter were the curiosity and the interest in allocating the sites and routes of migration of the reservoirs of the mesenchymal precartilaginous stem cells of the developing limbs in health and in disease. We chose to emphasize the events believed to initiate in these regions of stem cells, which may lead to growth retardation disorders. Thus, this narrow niche touches an enlarged scope of developmental biology angles and fields. The enclosed coverage sheds light on part of the musculoskeletal system, skeletogenesis, organogenesis of mobile structures and organs, the limbs, joints and digits (arthrology). It appears that the key role of the cartilage-bone regions is their responsibility to replenish the physis with committed chondrocytes, during the developmental, maturation and puberty periods. We shall start by outlining the framework of normal limb formation, the modalities, signals and the agents participating in this biological creation and regulation, illustrating potential sites that might deviate from normal development during the growth periods.
- Subjects :
- Endocrinology, Diabetes and Metabolism
Organogenesis
Bone Neoplasms
Biology
Endocrinology
Arthrology
Animals
Humans
Insulin-Like Growth Factor I
Skeletal growth
Growth Disorders
Limb formation
Bone Development
Growth retardation
Mesenchymal stem cell
Extremities
Mesenchymal Stem Cells
Anatomy
Cartilage
Pediatrics, Perinatology and Child Health
Bone Morphogenetic Proteins
Stem cell
Bone Diseases
Neuroscience
Developmental biology
Epiphyses
Subjects
Details
- ISSN :
- 0334018X
- Volume :
- 23
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric endocrinologymetabolism : JPEM
- Accession number :
- edsair.doi.dedup.....fb88866e81496b621f65f48ff0da7ff3