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Tissue plasminogen activator levels change with plasma fibrinogen concentrations during pregnancy
- Source :
- Annals of Hematology. 81:611-615
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- To investigate the relationship between coagulation activities and the fibrinolytic system during normal pregnancy, we measured the plasma concentrations of coagulation factors, antithrombin III (AT III), D-dimer, tissue plasminogen activator (tPA), total protein S (TPS), and plasminogen activator inhibitor type 1 (PAI-1) in 436 apparently healthy pregnant, postpartum, and nonpregnant women. There were no significant changes in AT III, TPS, and factor XI concentrations during pregnancy and puerperium. However, factor VII, VIII, IX, and XII activities increased gradually as pregnancy progressed, reached maximum values in the third trimester, and returned to nonpregnant levels by 5-8 weeks postpartum. Plasma D-dimer levels in the third trimester of pregnancy were 1.23+/-0.42 micro g/ml, significantly higher than for the first trimester (0.34+/-0.16 micro g/ml, P
- Subjects :
- Adult
medicine.medical_specialty
Fibrinogen
Tissue plasminogen activator
Statistics, Nonparametric
Fibrin Fibrinogen Degradation Products
chemistry.chemical_compound
Pregnancy
Internal medicine
medicine
Humans
Blood Coagulation
Blood coagulation test
Hematology
Factor VII
business.industry
Postpartum Period
Antithrombin
General Medicine
medicine.disease
Blood Coagulation Factors
Endocrinology
Coagulation
chemistry
Tissue Plasminogen Activator
Female
Blood Coagulation Tests
Pregnancy Trimesters
business
medicine.drug
Subjects
Details
- ISSN :
- 14320584 and 09395555
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Annals of Hematology
- Accession number :
- edsair.doi.dedup.....fb86b834d14744dc0ad35fb29fd098c8