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Getting into chromatin: how do transcription factors get past the histones?
- Source :
- Biochemistry and cell biology = Biochimie et biologie cellulaire. 81(3)
- Publication Year :
- 2003
-
Abstract
- Transcriptional activators and the general transcription machinery must gain access to DNA that in eukaryotes may be packaged into nucleosomes. In this review, I discuss this problem from the standpoint of the types of chromatin structures that these DNA-binding proteins may encounter, and the mechanisms by which they may contend with various chromatin structures. The discussion includes consideration of experiments in which chromatin structure is manipulated in vivo to confront activators with nucleosomal binding sites, and the roles of nucleosome dynamics and activation domains in facilitating access to such sites. Finally, the role of activators in facilitating access of the general transcriptional machinery to sites in chromatin is discussed. Key words: nucleosome, chromatin, transcriptional activation, Saccharomyces cerevisiae.
- Subjects :
- Models, Molecular
Histone-modifying enzymes
Transcription, Genetic
Computational biology
Biology
Biochemistry
Models, Biological
Chromatin remodeling
Histones
Nucleosome
Histone code
Animals
Humans
Molecular Biology
Transcription factor
Genetics
Binding Sites
Cell Biology
DNA
Chromatin
Nucleosomes
Histone
biology.protein
DNase I hypersensitive site
Transcription Factors
Subjects
Details
- ISSN :
- 08298211
- Volume :
- 81
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biochemistry and cell biology = Biochimie et biologie cellulaire
- Accession number :
- edsair.doi.dedup.....fb789c6b801b4a9a72d2fd90aa7982e0