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Treatment failure following excision therapy of CIN: the impact of ă direct colposcopic vision during procedure
- Source :
- Archives of Gynecology and Obstetrics, Archives of Gynecology and Obstetrics, Springer Verlag, 2016, 293 (4), pp.825-831. ⟨10.1007/s00404-015-3887-7⟩, Archives of Gynecology and Obstetrics, 2016, 293 (4), pp.825-831. ⟨10.1007/s00404-015-3887-7⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; To assess whether the use of direct colposcopic vision during excision ă therapy of cervical intraepithelial neoplasia (CIN) has an impact on the ă risk of treatment failure. ă Data from 285 patients who had had excision therapy with proven CIN at ă specimen histological analysis were reviewed. Primary endpoint was the ă occurrence of post-treatment failure defined by the histological ă diagnosis of CIN 2-3 during follow-up. Data were analysed according to ă the use of colposcopy at the time of initial therapy of CIN. ă The use of direct colposcopic vision (DCV) resulted in a significant ă reduction in the mean height (p = 0.008) and diameter (p < 0.001) of the ă excised specimen. Patients' median follow-up was 28.4 (+/- 1.3) months. ă A total of 43 (15.2 %) patients were diagnosed with treatment failure. ă Compared to excisions performed without any use of colposcopy, DCV was ă not found to have any significant impact on the risk of treatment ă failure (HR: 0.58; 95 % CI 0.16-2.13, p = 0.412), neither when compared ă to excisions performed immediately after colposcopy (HR: 0.91; 95 % CI ă 0.47-1.79; p = 0.794). The only factors found to have a significant ă impact on the risk of treatment failure was the identification of clear ă margins (HR: 0.36; 95 %CI 0.19-0.69; p = 0.002) and the diameter of the ă surgical specimen (HR: 0.94; 95 %CI 0.89-0.99; p = 0.040). ă Although the use of DCV during excision therapy of CIN was associated ă with a significant reduction in the dimensions of the excised cervical ă specimen, it did not result in a significant change in the risk of ă treatment failure.
- Subjects :
- Adult
Risk
medicine.medical_specialty
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Uterine Cervical Neoplasms
[SHS.PSY]Humanities and Social Sciences/Psychology
Cervix Uteri
Surgical specimen
Cervical intraepithelial neoplasia
Treatment failure
[SHS.PSY] Humanities and Social Sciences/Psychology
03 medical and health sciences
0302 clinical medicine
Pregnancy
Histological diagnosis
Clinical endpoint
medicine
Humans
Treatment Failure
030212 general & internal medicine
[SHS.ECO] Humanities and Social Sciences/Economics and Finance
Colposcopy
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Obstetrics and Gynecology
General Medicine
During procedure
Middle Aged
Uterine Cervical Dysplasia
medicine.disease
[SHS.ECO]Humanities and Social Sciences/Economics and Finance
Quality
3. Good health
Surgery
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Subjects
Details
- Language :
- English
- ISSN :
- 09320067 and 14320711
- Database :
- OpenAIRE
- Journal :
- Archives of Gynecology and Obstetrics, Archives of Gynecology and Obstetrics, Springer Verlag, 2016, 293 (4), pp.825-831. ⟨10.1007/s00404-015-3887-7⟩, Archives of Gynecology and Obstetrics, 2016, 293 (4), pp.825-831. ⟨10.1007/s00404-015-3887-7⟩
- Accession number :
- edsair.doi.dedup.....fb6d6d8540a2992b8b468c60218130f1