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Roles of NIPBL in maintenance of genome stability
- Source :
- Seminars in Cell & Developmental Biology. 90:181-186
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- A cohesin-loading factor (NIPBL) is one of important regulatory factors in the maintenance of 3D genome organization and function, by interacting with a large number of factors, e.g. cohesion, CCCTC-binding factor (CTCF) or cohesin complex component. The present article overviews the critical and regulatory roles of NIBPL in cohesion loading on chromotin and in gene expression and transcriptional signaling. We explore molecular mechanisms by which NIPBL recruits endogenous histone deacetylase (HDAC) to induce histone deacetylation and influence multi-dimensions of genome, through which NIPBL “hop” movement in chromatin regulates gene expression and alters genome folding. NIPBL regulates the process of CTCF and cohesion into chromatin loops and topologically associated domains, binding of cohesion and H3K4mes3 through interaction among promoters and enhancers. HP1 recruits NIPBL to DNA damage site through RNF8/RNF168 ubiquitylation pathway. NIPBL contributes to regulation of genome-controlled gene expression through the influence of cohesin in chromosome structure. NIPBL interacts with cohesin and then increases transcriptional activities of REC8 promoter, leading to up-regulation of gene expression. NIPBL movement among chromosomal loops regulates gene expression through dynamic alterations of genome organization. Thus, we expect a new and deep insight to understand dynamics of chromosome and explore potential strategies of therapiesc on basis of NIPBL.
- Subjects :
- 0301 basic medicine
biology
Cohesin complex
Cohesin
Gene Expression
Cell Cycle Proteins
NIPBL
Cell Biology
Genomic Instability
Chromatin
Cell biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Histone
CTCF
biology.protein
Chromosomes, Human
Humans
Heterochromatin protein 1
Enhancer
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 10849521
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Seminars in Cell & Developmental Biology
- Accession number :
- edsair.doi.dedup.....fb5ff03c373580e4d00f615e071b889b
- Full Text :
- https://doi.org/10.1016/j.semcdb.2018.08.005