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Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study
- Source :
- Food and Chemical Toxicology, 38, 599-605. Elsevier Science, Food and Chemical Toxicology, 7, 38, 599-605
- Publication Year :
- 2000
-
Abstract
- Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and women aged 55 to 69 years. A semi-quantitative food frequency questionnaire was used to assess food consumption. Information on BHA or BHT content of cooking fats, oils, mayonnaise and other creamy salad dressings and dried soups was obtained by chemical analysis, a Dutch database of food additives (ALBA) and the Dutch Compendium of Foods and Diet Products. After 6.3 years of follow-up, complete data on BHA and BHT intake of 192 incident stomach cancer cases and 2035 subcohort members were available for case-cohort analysis. Mean intake of BHA or BHT among subcohort members was 105 and 351 μg/day, respectively. For consumption of mayonnaise and other creamy salad dressings with BHA or BHT no association with stomach cancer risk was observed. A statistically non-significant decrease in stomach cancer risk was observed with increasing BHA and BHT intake [rate ratio (RR) highest/lowest intake of BHA=0.57 (95% confidence interval (CI): 0.25-1.30] and BHT=0.74 (95% CI: 0.38-1.43). In this study, no significant association with stomach cancer risk was found for usual intake of low levels of BHA and BHT. Copyright (C) 2000 Elsevier Science Ltd. Chemicals/CAS: Antioxidants; Butylated Hydroxyanisole, 25013-16-5; Butylated Hydroxytoluene, 128-37-0; Food Additives
- Subjects :
- Male
Questionnaires
Antioxidant
medicine.medical_treatment
Butylated Hydroxyanisole
Toxicology
Antioxidants
Cohort Studies
chemistry.chemical_compound
Cancer risk
Food intake
Surveys and Questionnaires
Pathology
Medicine
Butylated hydroxytoluene
Chemical analysis
Food science
Prospective Studies
Stomach cancer
Prospective cohort study
Netherlands
Stomach
General Medicine
Middle Aged
Oil
medicine.anatomical_structure
Statistical analysis
Female
Butylated hydroxyanisole
Cohort analysis
Cohort study
Human
Adult
No-observed-adverse-effect level
food.ingredient
Stomach neoplasms
Risk Assessment
Geneeskunde
food
Humans
Nutrition
Aged
Pharmacology
No-Observed-Adverse-Effect Level
business.industry
Questionnaire
Food additive
Dietary intake
Food analysis
Butylated Hydroxytoluene
medicine.disease
Diet
Butylcresol
chemistry
Fat
Food Additives
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 02786915
- Database :
- OpenAIRE
- Journal :
- Food and Chemical Toxicology, 38, 599-605. Elsevier Science, Food and Chemical Toxicology, 7, 38, 599-605
- Accession number :
- edsair.doi.dedup.....fb5d08df14d7f3f146b40af4fd054b3c