LGI1 antibody encephalitis and psychosis

Objective: To describe a case of leucine-rich, glioma inactivated 1 antibody-encephalitis presenting with psychosis. Methods: Case report. Results: A young man with leucine-rich, glioma inactivated 1-antibody encephalitis initially presented with acute psychotic symptoms, short-term memory loss and faciobrachial dystonic seizures. Magnetic resonance imaging revealed hippocampal lesions. Electroencephalography revealed frontotemporal slowing of background activity. Conclusion: Increased awareness of leucine-rich, glioma inactivated 1-antibody encephalitis may promote early recognition and treatment.