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Reversal of isoprenaline-induced cardiac remodeling by rutaecarpine via stimulation of calcitonin gene-related peptide production

Authors :
Han-Wu DengH.W. Deng
Yuan-Jian LiY.-J. Li
Li XiaoL. Xiao
Mei-Chun LiaoM.C. Liao
Chang-Ping HuC.-P. Hu
Jun PengJ. Peng
Jian-Zhe LiJ.Z. Li
Yi-Shuai ZhangY.-S. Zhang
Xiao-Hui LiX.H. Li
Source :
Canadian Journal of Physiology and Pharmacology. 88:949-959
Publication Year :
2010
Publisher :
Canadian Science Publishing, 2010.

Abstract

Dysfunction of capsaicin-sensitive sensory nerves is involved in cardiac remodeling, and rutaecarpine has been shown to exert a beneficial effect on cardiac function through activating the sensory nerves. This study was conducted to explore the potential inhibitory effect of rutaecarpine on cardiac remodeling and the underlying mechanisms. A rat cardiac remodeling model was established by injection of isoprenaline (5 mg/kg per day, s.c.) for 10 days. Rutaecarpine (10 or 40 mg/kg, i.g.) was coadministrated with isoprenaline to evaluate the effect of rutaecarpine on cardiac remodeling. After echocardiographic analysis was performed, blood samples were collected to quantify calcitonin gene-related peptide (CGRP), dorsal root ganglia were isolated for examining CGRP mRNA expression, and the hearts were weighed and saved for evaluating the parameters related to apoptosis and hypertrophy. Isoprenaline significantly increased the ratio of left ventricle weight to body weight, the cross-sectional area of cardiomyocytes, cardiac apoptosis, and collagen deposition concomitantly with decreased CGRP production, which were reversed by rutaecarpine treatment. The beneficial effects of rutaecarpine were attenuated by pretreatment with capsaicin, which selectively depleted CGRP. These results suggest that rutaecarpine was able to reverse isoprenaline-induced cardiac remodeling through stimulating CGRP production.

Details

ISSN :
12057541 and 00084212
Volume :
88
Database :
OpenAIRE
Journal :
Canadian Journal of Physiology and Pharmacology
Accession number :
edsair.doi.dedup.....fb5895c4ab89d9c689c82489a46a9d1a
Full Text :
https://doi.org/10.1139/y10-067