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Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan
- Source :
- Cancer Medicine, Cancer Medicine, Vol 10, Iss 12, Pp 3848-3861 (2021)
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real‐world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1–75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2–357). Adverse events occurred in 12.7%. Life‐threatening complications occurred in 0.5%, but there were no treatment‐related deaths. During a median follow‐up period of 46.1 months (range 1–113), the 3‐year overall survival rate, relapse‐free survival rate, cause‐specific survival rate, and larynx‐preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN000008276.<br />This is the first report on nationwide survival data and pathological criteria of superficial head and neck cancer. Transoral surgery for superficial head and neck cancer was safe and offered highly curative minimally invasive treatment preserving organs and their function. Subepithelial invasion was clinically useful predictor of recurrence after transoral surgery.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
larynx preservation
pharyngeal cancer
transoral surgery
Severity of Illness Index
0302 clinical medicine
Postoperative Complications
Japan
RC254-282
Original Research
Aged, 80 and over
Incidence (epidemiology)
Incidence
superficial cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Neoplasms, Second Primary
Middle Aged
Tumor Burden
Survival Rate
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Female
Larynx
Carcinoma in Situ
Adult
Natural Orifice Endoscopic Surgery
medicine.medical_specialty
Operative Time
Disease-Free Survival
03 medical and health sciences
medicine
Humans
Radiology, Nuclear Medicine and imaging
Adverse effect
Survival rate
Pathological
Aged
Retrospective Studies
business.industry
Squamous Cell Carcinoma of Head and Neck
Head and neck cancer
Clinical Cancer Research
medicine.disease
Head and neck squamous-cell carcinoma
Surgery
Clinical trial
030104 developmental biology
head and neck cancer
Transoral surgery
business
Organ Sparing Treatments
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 10
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....fb4ab94caa88f3ad1d897d88c11a78d1