Back to Search
Start Over
Vascular endothelial growth factor staining and elevated INR in advanced epithelial ovarian carcinoma
- Source :
- Journal of Surgical Oncology. 96:514-517
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Background The purpose of this study was to determine whether vascular endothelial growth factor (VEGF) expression in tumors correlates with the incidence of an elevated prothrombin time (PT), specifically an international normalized ratio (INR) ≥ 1.4, in patients undergoing primary surgical cytoreduction for ovarian cancer. Methods INRs were obtained on all patients perioperatively. VEGF expression was determined by immunostaining of tumor specimens using published protocols. Results One hundred patients underwent surgical cytoreduction. Sixty-seven percent of patients had postoperative INR of 1.4 or greater. INRs of greater than or equal to 1.8 were found in 5% of patients. INR elevation was independent of mean estimated blood loss (EBL) with the EBL in the patients with INRs ≥ 1.4 not significantly different than the EBL in the patients with INRs
- Subjects :
- Vascular Endothelial Growth Factor A
endocrine system
medicine.medical_specialty
VEGF receptors
Urology
Perioperative Care
chemistry.chemical_compound
health services administration
medicine
Coagulopathy
Humans
heterocyclic compounds
International Normalized Ratio
cardiovascular diseases
Ovarian Neoplasms
biology
business.industry
Incidence (epidemiology)
fungi
General Medicine
medicine.disease
Immunohistochemistry
Surgery
Staining
Vascular endothelial growth factor
Oncology
chemistry
Epithelial ovarian carcinoma
Prothrombin Time
biology.protein
Female
Ovarian cancer
business
Immunostaining
Subjects
Details
- ISSN :
- 10969098 and 00224790
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....fb478fd7726458af343d446b105ec986