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Differential expression of microRNAs in TM3 Leydig cells of mice treated with brain-derived neurotrophic factor
- Source :
- Cell Biochemistry and Function. 35:364-371
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Brain-derived neurotrophic factor (BDNF) is a neurotrophin that can promote the development and proliferation of neurons. BDNF has been found to be involved in male reproduction. Leydig cells in testicular interstitial tissues can secrete testosterone in a luteinizing hormone-dependent manner. We showed that BDNF and its receptor TrkB were expressed in mice TM3 Leydig cells in the present study. Furthermore, BDNF can promote proliferation of mouse TM3 Leydig cells in vitro. Results of microRNA (miRNA) deep sequencing showed that BDNF can alter the expression profile of miRNAs in TM3 Leydig cells. Eighty-three miRNAs were significantly different in the BDNF-treated and control groups (fold change of >2.0 or
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Clinical Biochemistry
Down-Regulation
Tropomyosin receptor kinase B
Biology
Real-Time Polymerase Chain Reaction
Biochemistry
Cell Line
Mice
03 medical and health sciences
0302 clinical medicine
Neurotrophic factors
Internal medicine
microRNA
medicine
Animals
Receptor, trkB
Receptor
Cell Proliferation
Brain-derived neurotrophic factor
Sequence Analysis, RNA
Brain-Derived Neurotrophic Factor
Computational Biology
High-Throughput Nucleotide Sequencing
Leydig Cells
Cell Biology
General Medicine
Fold change
Up-Regulation
MicroRNAs
030104 developmental biology
Endocrinology
Microscopy, Fluorescence
030220 oncology & carcinogenesis
biology.protein
Signal transduction
Signal Transduction
Neurotrophin
Subjects
Details
- ISSN :
- 02636484
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Cell Biochemistry and Function
- Accession number :
- edsair.doi.dedup.....fb279109bd844d01226d8695614bbf32