Effects of Metrizoate and Iohexol on the Liver at Visceral Angiography

Hepatic angiography was performed in a double-blind two-group study in 60 patients using iohexol 350 mg I/ml and ***metrizoate 350 mg I/ml. A slight increase in serum values of hepatic enzymes was found when metrizoate was used, particularly in patients with impaired liver function. Iohexol gave considerably less pain and sensation of heat than did metrizoate. A non-expected significant increase of creatine kinase was recorded when iohexol was used. The reason for this is not yet known.