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Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease
- Source :
- Archives of Medical Sciences. Atherosclerotic Diseases
- Publication Year :
- 2016
-
Abstract
- Introduction: Serum procalcitonin (PCT) levels are known to be low in healthy individ­uals in healthy subjects but are increased in patients with a severe bacterial infection. It has not been extensively studied in children with chronic kidney disease (CKD), treated either with hemodialysis (HD) or with renal transplantation. Material and methods: During a 6-month period, blood samples were taken from 102 (55 HD children and 47 renal transplant recipients) children with a strong clinical suspicion of infection. Procalcitonin levels were measured by ELISA. Results: Thirty-four/102 cases had proven infections as defined previously. Children with proven infections had a significantly higher PCT (0.920 ±0.24 ng/ml) than those without (0.456 ±0.53 ng/ml), p = 0.04. The ideal cutoff value derived for serum PCT was 0.5 ng/ml. This threshold value established a sensitivity of 94.1% and a specificity of 87.9%. Conclusions: This study indicates that significantly increased PCT concentration is a promising predictor of systemic bacterial infection in children with CKD, with good sensitivity and specificity. This study proposes that serum PCT is a convenient index of infection in CKD children at a cutoff value of 0.5 ng/ml.
- Subjects :
- medicine.medical_specialty
Pathology
medicine.medical_treatment
Gastroenterology
Procalcitonin
children
Clinical Research
Internal medicine
parasitic diseases
medicine
Diagnostic biomarker
In patient
hemodialysis
business.industry
Healthy subjects
General Medicine
medicine.disease
infection
Transplantation
Renal transplant
Hemodialysis
business
hormones, hormone substitutes, and hormone antagonists
chronic kidney disease
procalcitonin
cutoff value
Kidney disease
transplantation
Subjects
Details
- ISSN :
- 24510629
- Volume :
- 1
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Archives of medical sciences. Atherosclerotic diseases
- Accession number :
- edsair.doi.dedup.....fb0d5b91964f48d5dcd6f731e54cfe9c