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Efficacy of cultured epithelial autografts in pediatric burns and reconstructive surgery
- Source :
- Surgery. 121:654-661
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- Background . Cultured epithelial autografts are regularly used in burn patients, but they have not been tested in patients undergoing reconstructive surgery. The aim of this study was to analyze and compare the efficacy of cultured grafts in both burn and reconstructive surgery patients. Methods . In six children with severe and massive burns, full-thickness areas were grafted with cultured grafts. In another six children with hypertrophic or hyperpigmented scars, or both, cultured grafts were used to cover defects resulting from scar excision or deep dermabrasion. Results . In burn surgery the final cover rate averaged 60% (range, 0% to 100%). The functional and cosmetic results were good and at least equivalent to results after conventional grafting. Fragility, infection, and, in particular, mechanical instability of cultured grafts during the first weeks after transplantation were, the main problems encountered. In reconstructive surgery the final cover rate was 100% in all patients. The functional and cosmetic results were very good and considered better than those obtained by using conventional grafting techniques. No major management problems were encountered. Conclusions . In massively burned children, cultured epithelial autografts represent an effective additional and potentially lifesaving method to conventional grafting. Questions remain regarding the use of this technique to treat less severe burns. For resurfacing-type scar revisions, cultured epithelial autografts yield excellent results that appear to be superior to those of conventional techniques.
- Subjects :
- Male
Scar Excision
medicine.medical_specialty
Reconstructive surgery
Adolescent
medicine.medical_treatment
Scars
Transplantation, Autologous
Epithelium
Cicatrix
medicine
Humans
In patient
Child
Cells, Cultured
Mechanical instability
business.industry
Dermabrasion
Skin Transplantation
Surgery
Transplantation
Plastic surgery
surgical procedures, operative
Child, Preschool
Female
medicine.symptom
Burns
business
Subjects
Details
- ISSN :
- 00396060
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- Surgery
- Accession number :
- edsair.doi.dedup.....fafd8227e02022095e1b1841a9537eb8