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Quantitative assessment of atrial conduit function: a new index of diastolic dysfunction
- Source :
- Clinical Research in Cardiology
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Background Heart failure (HF) epidemic has increased need for accurate diastolic dysfunction (DD) quantitation. Cardiac MRI can elucidate left atrial (LA) phasic function, and accurately quantify its conduit contribution to left ventricular (LV) filling, but has limited availability. We hypothesized that the percentage of LV stroke volume due to atrial conduit volume (LACV), as assessed using 3D-echocardiography, can differentiate among progressive degrees of DD in HF patients. Methods and results Sixty-three subjects (66 ± 12 years) with DD and ejection fraction (EF) ranging 14–62 % underwent full-volume 3D-echocardiography. Simultaneous LA and LV volume curves as function of time (t) were calculated, with LACV as \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{LACV}}\left( t \right) \, = \, \left[ {{\text{LV}}\left( t \right){-}{\text{LV minimum}}} \right] \, - \, \left[ {{\text{LA maximum }} - {\text{ LA}}\left( t \right)} \right]$$\end{document}LACVt=LVt-LV minimum-LA maximum-LAt, expressed as % of stroke volume. Patients were assigned to four (0–3, from none to severe) DD grades, according to classical Doppler parameters. In this population DD is linked to LACV, with progressively higher percentages of conduit contribution to stroke volume associated with higher degrees of DD (p = 0.0007). Patients were then dichotomized into no-mild (n = 26) or severe (n = 37) DD groups. Apart from atrial volume, larger (p
- Subjects :
- Male
medicine.medical_specialty
Echocardiography, Three-Dimensional
Diastole
030204 cardiovascular system & hematology
Doppler echocardiography
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Electrical conduit
Left atrial
Internal medicine
Severity of illness
medicine
Quantitative assessment
Humans
cardiovascular diseases
030212 general & internal medicine
Aged
Heart Failure
Original Paper
medicine.diagnostic_test
business.industry
Stroke Volume
General Medicine
Stroke volume
Middle Aged
medicine.disease
Echocardiography, Doppler
Left atrial conduit function
Heart failure
cardiovascular system
Cardiology
Diastolic dysfunction
Atrial Function, Left
Female
Full-volume 3D-echocardiography
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 18610692 and 18610684
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Clinical Research in Cardiology
- Accession number :
- edsair.doi.dedup.....fafb5aada636bd902ffb3522657168ae