Back to Search
Start Over
Neurohormones, Rikkunshito and Hypothalamic Neurons Interactively Control Appetite and Anorexia
- Source :
- ResearcherID
- Publication Year :
- 2012
- Publisher :
- Bentham Science Publishers Ltd., 2012.
-
Abstract
- Ghrelin is the orexigenic peptide produced in the periphery, and its plasma level shows remarkable pre/postprandial changes. Ghrelin is considered a pivotal signal to the brain to stimulate feeding. Hence, characterizing the target neurons for ghrelin in the hypothalamic feeding center and the signaling cascade in the target neurons are essential for understanding the mechanisms regulating appetite. Anorexia and cachexia associated with gastric surgery, stress-related diseases, and use of anti-cancer drugs cause the health problems, markedly deteriorating the quality of life. The anorexia involves several neurotransmitters and neuropeptides in the hypothalamic feeding center, in which corticotropin-releasing hormone (CRH), urocortine, serotonin (5HT) and brain-derived neurotrophic factor (BDNF) play a pivotal role. A Japanese herbal medicine, rikkunshito, has been reported to ameliorate the anorexia by promoting the appetite. This review describes 1) the interaction of ghrelin with the orexigenic neuropeptide Y (NPY) neurons in the hypothalamic arcuate nucleus (ARC) and underlying signaling cascade in NPY neurons, 2) the anorectic pathway driven by BDNF-CRH/urocortine and 5HTCRH/ urocortine pathways, 3) the effect of rikkunshito on the interaction of ghrelin and NPY neurons in ARC, and 4) the effect of rikkunshito on the interaction of 5HT on CRH neurons in paraventricular nucleus (PVN).
- Subjects :
- endocrine system
medicine.medical_specialty
media_common.quotation_subject
Hypothalamus
Appetite Stimulants
Neuropeptide
Anorexia
Arcuate nucleus
Internal medicine
Orexigenic
Drug Discovery
medicine
Animals
Humans
Neuropeptide Y
media_common
Neurons
Pharmacology
Neurotransmitter Agents
Appetite Regulation
business.industry
digestive, oral, and skin physiology
Appetite
Lipid Metabolism
Neuropeptide Y receptor
Ghrelin
Endocrinology
nervous system
Anorectic
medicine.symptom
Energy Intake
business
hormones, hormone substitutes, and hormone antagonists
Drugs, Chinese Herbal
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....fae61ff4027315d81b1916ca216ee20e