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Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group UK, 2017.
-
Abstract
- High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their encoded proteins. We systematically compared the expression of 4436 genes on the RNA and protein levels between discrete tumor samples collected from the ovary and from the omentum of the same OC patient. The overall correlation between global changes in levels of mRNA and their encoding proteins is low (r = 0.38). The majority of differences are on the protein level with no corresponding change on the mRNA level. Indirect and direct evidence indicates that a significant fraction of the differences may be mediated by microRNAs.
- Subjects :
- 0301 basic medicine
Science
Biology
Bioinformatics
Article
Transcriptome
03 medical and health sciences
0302 clinical medicine
RNA interference
microRNA
Protein biosynthesis
Humans
RNA, Messenger
RNA Processing, Post-Transcriptional
skin and connective tissue diseases
Neoplasm Staging
Regulation of gene expression
Ovarian Neoplasms
Messenger RNA
Multidisciplinary
Gene Expression Profiling
Ovary
RNA
Computational Biology
3. Good health
Cell biology
Gene expression profiling
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Protein Biosynthesis
Disease Progression
Medicine
Female
RNA Interference
sense organs
Neoplasm Grading
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....fae0213f04aa530057588cc69750305f