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PET of Glucose Metabolism and Cellular Proliferation in Prostate Cancer
- Source :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 57(Suppl 3)
- Publication Year :
- 2016
-
Abstract
- Imaging of the Warburg effect, which is the principal but not the sole cause for enhanced glucose metabolism in tumors, with PET and 18F-FDG has become the mainstay for the imaging evaluation of several cancers. Despite the seemingly prevalent notion that 18F-FDG PET may not be useful in prostate cancer, relatively limited evidence suggests that this imaging modality can be useful for the evaluation of the extent of metastatic disease and the assessment of the therapy response and prognosis in men with castration-resistant prostate cancer. Incidental high focal 18F-FDG uptake in the prostate gland, although generally rare, may also indicate occult prostate cancer that may need to be further scrutinized. In general, 18F-FDG PET is not useful for initial staging and is of limited utility in the clinical setting of biochemical failure after prior definitive therapy for primary cancer. Although more experience is needed, it appears that the imaging of cellular proliferation with PET and 3'-deoxy-3'-18F-fluorothymidine or 2'-18F-fluoro-5-methyl-1-β-d-arabinofuranosyluracil may also allow for targeted biopsy and localization for focal therapy of aggressive prostate tumors as well as assessment of the therapy response to various standard and novel treatment regimens in patients with metastatic disease.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Definitive Therapy
Disease
Carbohydrate metabolism
030218 nuclear medicine & medical imaging
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Fluorodeoxyglucose F18
Internal medicine
medicine
Biomarkers, Tumor
Humans
Radiology, Nuclear Medicine and imaging
In patient
Neoplasm Invasiveness
Cell Proliferation
PET-CT
Evidence-Based Medicine
business.industry
Prostatic Neoplasms
medicine.disease
Occult
Warburg effect
Molecular Imaging
Glucose
030220 oncology & carcinogenesis
Lymphatic Metastasis
Positron-Emission Tomography
Radiopharmaceuticals
business
Supplement
Subjects
Details
- ISSN :
- 15355667
- Volume :
- 57
- Issue :
- Suppl 3
- Database :
- OpenAIRE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....fad5bfd0a3614c1f14a2086a4bc45303