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Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions
- Source :
- Multiple Sclerosis Journal. 22:1289-1296
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- Background: White matter lesions are frequently detected using brain magnetic resonance imaging (MRI) performed for various indications. Most are microangiopathic, but demyelination, including multiple sclerosis (MS), is an important cause; conventional MRI cannot always distinguish between these pathologies. The proportion of lesions with a central vein on 7-T T2*-weighted MRI prospectively distinguishes demyelination from microangiopathic lesions. Objective: To test whether 3-T T2*-weighted MRI can differentiate MS from microangiopathic brain lesions. Methods: A total of 40 patients were studied. Initially, a test cohort of 10 patients with MS and 10 patients with microangiopathic white matter lesions underwent 3-T T2*-weighted brain MRI. Anonymised scans were analysed blind to clinical data, and simple diagnostic rules were devised. These rules were applied to a validation cohort of 20 patients (13 with MS and 7 with microangiopathic lesions) by a blinded observer. Results: Within the test cohort, all patients with MS had central veins visible in >45% of brain lesions, while the rest had central veins visible in Conclusion: 3-T T2*-weighted brain MRI distinguishes perivenous MS lesions from microangiopathic lesions. Clinical application of this technique could supplement existing diagnostic algorithms.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Multiple Sclerosis
Sensitivity and Specificity
Veins
030218 nuclear medicine & medical imaging
Diagnosis, Differential
White matter
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
Aged
medicine.diagnostic_test
business.industry
Multiple sclerosis
Brain
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
White Matter
Hyperintensity
medicine.anatomical_structure
Neurology
Case-Control Studies
Cerebral Small Vessel Diseases
Brain lesions
Female
Neurology (clinical)
Radiology
Central veins
Differential diagnosis
business
T2 weighted
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14770970 and 13524585
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis Journal
- Accession number :
- edsair.doi.dedup.....fad48e12350418477cae9a3b7c664477