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A single mouse gene encodes the mitochondrial transcription factor A and a testis–specific nuclear HMG-box protein
- Source :
- Nature Genetics. 13:296-302
- Publication Year :
- 1996
- Publisher :
- Springer Science and Business Media LLC, 1996.
-
Abstract
- Mitochondrial transcription factor A (mtTFA) is a key regulator of mammalian mitochondrial DNA transcription. We report here that a testis-specific isoform of mouse mtTFA lacks the mitochondrial targeting sequence and is present in the nucleus of spermatocytes and elongating spermatids, thus representing the first reported mammalian gene encoding protein isoforms targeted for the mitochondria or the nucleus. The presence of the mitochondrial transcriptional activator in the nucleus raises the possibility of a role for this protein in both genetic systems. Mutations in the nuclear mtTFA gene may therefore exhibit phenotypic consequences due to altered function in either or both genetic compartments.
- Subjects :
- Male
Transcription, Genetic
Molecular Sequence Data
Mice, Inbred Strains
Biology
Mitochondrial Proteins
Mice
Sp3 transcription factor
Spermatocytes
Testis
Genetics
Animals
Amino Acid Sequence
NRF1
Cloning, Molecular
Transcription factor
HSPA9
Cell Nucleus
Sp1 transcription factor
Base Sequence
Sequence Homology, Amino Acid
High Mobility Group Proteins
Nuclear Proteins
Sequence Analysis, DNA
TCF4
TFAM
Molecular biology
Mitochondria
DNA-Binding Proteins
TAF2
Transcription Factors
Subjects
Details
- ISSN :
- 15461718 and 10614036
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nature Genetics
- Accession number :
- edsair.doi.dedup.....fac79abe97f3439c1100053f49c1bb77