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Flow-volume loops measured with electrical impedance tomography in pediatric patients with asthma
- Source :
- Pediatric Pulmonology. 53:636-644
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background Electrical impedance tomography (EIT) provides information on global and regional ventilation during tidal breathing and mechanical ventilation. During forced expiration maneuvers, the linearity of EIT and spirometric data has been documented in healthy persons. The present study investigates the potential diagnostic use of EIT in pediatric patients with asthma. Methods EIT and spirometry were performed in 58 children with asthma (average age ± SD: 11.86 ± 3.13 years), and 58 healthy controls (average age ± SD: 12.12 ± 2.9 years). The correlation between EIT data and simultaneously acquired spirometric data were tested for FEV1, FEV0.5 , MEF75 , MEF50 , and MEF25 . Binary classification tests were performed for the EIT-derived Tiffeneau index FEV1 /FVC and the bronchodilator test index ΔFEV1 . Average flow-volume (FV) loops were generated for patients with pathologic spirometry to demonstrate the feasibility of EIT for graphic diagnosis of asthma. Results Spirometry and global EIT-based FV loops showed a strong correlation (P 0.9 in FEV1 and FEV0.5 ). In all criteria, the binary classification tests yielded high specificity (>93%), a high positive predictive value (≥75%) and a high negative predictive value (>80%), while sensitivity was higher in ΔFEV1 (86.67%) and lower in FEV1 /FVC (25% and 35.29%). A typical concave shape of the EIT-derived average FV loops was observed for asthmatic children with improvement after bronchospasmolysis. Conclusions Global FV loops derived from EIT correlate well with spirometry. Positive bronchospasmolysis can be observed in EIT-derived FV loops. Flow-volume loops originated from EIT have a potential to visualize pulmonary function.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Adolescent
medicine.drug_class
medicine.medical_treatment
0206 medical engineering
02 engineering and technology
Pulmonary function testing
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
Bronchodilator
Internal medicine
Electric Impedance
medicine
Humans
Child
Lung
Tomography
Electrical impedance tomography
Asthma
Mechanical ventilation
medicine.diagnostic_test
business.industry
medicine.disease
020601 biomedical engineering
Respiratory Function Tests
030228 respiratory system
Pediatrics, Perinatology and Child Health
Breathing
Cardiology
Female
business
Subjects
Details
- ISSN :
- 87556863
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Pediatric Pulmonology
- Accession number :
- edsair.doi.dedup.....faa44d646dbe0d2d88ed2e72f5134384