The Effects of Hypertransfusion on the Formation of Zones of Iron Concentration in the Spleen of the Mouse Radiation Chimera

The formation of zones of iron con centration in the spleen of the mouse radiation chimera is inhibited by transfusion-induced polycythaemia. This is consistent with the view that these zones represent colonies which contain aρ-preciable numbers of erythroblasts. On the surface of the spleen, such colonies outnumber colonies which do not accumulate iron by more than 4 to 1.