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Renal Abnormalities in Ankylosing Spondylitis
- Source :
- Scopus-Elsevier
- Publication Year :
- 1997
- Publisher :
- Informa UK Limited, 1997.
-
Abstract
- Renal abnormalities have been reported in Ankylosing Spondylitis (AS) patients. Possible mechanisms include the effects of nonsteroidal anti-inflammatory drugs (NSAIDs), an increased incidence of glomerulonephritis, particularly the ones associated with deposition of IgA-containing immune complexes and the renal deposition of amyloid. These observations prompted us to evaluate in detail the frequency and severity of renal dysfunction in 40 AS patients, consecutively selected attending the rheumatology disease unit outpatient clinic at Escola Paulista de Medicina, using sensitive tests of glomerular and tubular function. Fourteen of the 40 patients presented one or more signs of renal involvement: microscopic hematuria (9 patients), microalbuminuria (4 patients), decreased renal function assessed by serum creatinine (2 patients), and creatinine clearance (4 patients). None of the patients presented increased urinary excretion of retinol binding protein (RBP). The finding of renal abnormalities in 35% of our patients suggests that in this illness evidence of renal involvement should be actively investigated.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Immunology
Renal function
Kidney
urologic and male genital diseases
Gastroenterology
chemistry.chemical_compound
Rheumatology
Internal medicine
medicine
Albuminuria
Humans
Immunology and Allergy
Outpatient clinic
Spondylitis, Ankylosing
Aged
Hematuria
Creatinine
Ankylosing spondylitis
Proteinuria
business.industry
Anti-Inflammatory Agents, Non-Steroidal
General Medicine
Middle Aged
medicine.disease
Surgery
chemistry
Female
Kidney Diseases
Microalbuminuria
medicine.symptom
business
Kidney disease
Subjects
Details
- ISSN :
- 15027732 and 03009742
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Rheumatology
- Accession number :
- edsair.doi.dedup.....fa9fbc6e6856a4951d6be5b19cc4dd6a