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The effect of leukocyte-platelet-rich fibrin on bone morphogenetic protein-2 and insulin-like growth factor-1 levels in patients with chronic periodontitis: a randomized split mouth clinical trail
- Source :
- Growth factors (Chur, Switzerland). 36(5-6)
- Publication Year :
- 2019
-
Abstract
- The present study evaluates the effects of leukocyte-platelet-rich fibrin (L-PRF) combined with open flap debridement (OFD) on clinical parameters and growth factors levels (GFL) in chronic periodontitis (CP) patients. This trial was registered at clinicaltrials.gov as NCT02594605. 16 patients (32 sites) with chronic periodontitis who had at least two areas of horizontal bone loss, were treated with OFD alone or L-PRF with OFD (OFD + L-PRF). GFL in gingival crevicular fluid (GCF) were analyzed at baseline, 1 week, 2 weeks and 4 weeks after operation. Probing depth (PD) and clinical attachment level (CAL) were measured at baseline and 6 months postoperatively. PD reduction and CAL gain were significantly higher in the OFD + L-PRF sites than in OFD sites. OFD + L-PRF group showed significantly increased bone morphogenetic protein-2 and insulin-like growth factor-1 at 2 weeks compared with baseline. L-PRF combined with OFD significantly increases GFL and thus, it enhances the periodontal healing on CP patients. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
- Subjects :
- Pathology
double blind procedure
Bone Regeneration
medicine.medical_treatment
Clinical Biochemistry
Gingiva
platelet-rich fibrin
Bone Morphogenetic Protein 2
wound healing
030204 cardiovascular system & hematology
Surgical Flaps
Insulin-like growth factor
0302 clinical medicine
Endocrinology
Postoperative Complications
BMP-2
Platelet-Rich Fibrin
Bone Morphogenetic Protein 2/metabolism
Chronic Periodontitis/*surgery
Debridement/adverse effects/*methods
Gingiva/metabolism
Humans
Insulin-Like Growth Factor I/metabolism
Postoperative Complications/*epidemiology
Surgical Flaps/surgery
Tissue Scaffolds/adverse effects/chemistry
Wound Healing
Medicine
Insulin-Like Growth Factor I
clinical article
biology
Tissue Scaffolds
drug effect
chronic periodontitis
Platelet-rich fibrin
priority journal
IGF-1
debridement
gingivitis
medicine.medical_specialty
bone morphogenetic protein 2
Bone morphogenetic protein 2
Article
Fibrin
03 medical and health sciences
controlled study
human
Periodontitis
open flap debridement
treatment duration
business.industry
Open flap debridement
030206 dentistry
Cell Biology
medicine.disease
somatomedin C
postoperative care
Chronic periodontitis
digestive system diseases
Debridement
randomized controlled trial
Chronic Periodontitis
biology.protein
osteolysis
business
Wound healing
Subjects
Details
- ISSN :
- 10292292
- Volume :
- 36
- Issue :
- 5-6
- Database :
- OpenAIRE
- Journal :
- Growth factors (Chur, Switzerland)
- Accession number :
- edsair.doi.dedup.....fa9d8253b5ba3f907e81ea0ff55f1825