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Experience of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma and relapsed/refractory systemic anaplastic large-cell lymphoma in the Named Patient Program: Review of the literature
- Source :
- Critical reviews in oncology/hematology. 95(3)
- Publication Year :
- 2014
-
Abstract
- Brentuximab vedotin was made available via a Named Patient Program (NPP) to non-US/Canadian patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) or systemic anaplastic large-cell lymphoma (sALCL) until approval in their respective countries. We re-evaluated the efficacy and safety NPP data in a pooled analysis. Through a systematic literature review, 21 NPP publications were identified describing 14 cohorts (N=245). Among patients with a specified diagnosis, 207 had HL, 28 had ALCL, and one had CD30+ T-cell lymphoma (not specified). In cohorts reporting response, overall response and complete remission rates were 67\% and 26\%, respectively, in R/R HL, and 75\% and 74\%, respectively, in R/R ALCL. Incidences of grade 3/4 neurologic and hematologic toxicities were 6\% and 12\%, respectively; 5\% of patients discontinued because of toxicity. In real-world practice, response rates and tolerability to brentuximab vedotin are similar to those reported in the two pivotal phase 2 trials in these settings.
- Subjects :
- Oncology
medicine.medical_specialty
Antibody-drug conjugate
Immunoconjugates
CD30
HL
Refractory
Recurrence
Internal medicine
hemic and lymphatic diseases
medicine
Humans
Brentuximab vedotin
Anaplastic large-cell lymphoma
Brentuximab Vedotin
business.industry
Hematology
medicine.disease
Hodgkin Disease
Lymphoma
Tolerability
Immunology
Hodgkin lymphoma
Lymphoma, Large-Cell, Anaplastic
business
medicine.drug
Subjects
Details
- ISSN :
- 18790461
- Volume :
- 95
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Critical reviews in oncology/hematology
- Accession number :
- edsair.doi.dedup.....fa931f9fcdebcff66e41ba25b0dbaf26