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Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies
- Source :
- Journal of Cancer Research and Clinical Oncology, Cassidy, James; Saltz, Leonard B.; Giantonio, Bruce J.; Kabbinavar, Fairooz F.; Hurwitz, Herbert I.; & Rohr, Ulrich-Peter. (2010). Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies. Journal of Cancer Research and Clinical Oncology, 136(5), pp 737-743. doi: 10.1007/s00432-009-0712-3. Retrieved from: http://www.escholarship.org/uc/item/5mc303k2
- Publication Year :
- 2009
- Publisher :
- Springer-Verlag, 2009.
-
Abstract
- Background Bevacizumab is frequently combined with 5-fluorouracil-based chemotherapy for patients with metastatic colorectal cancer (mCRC). The relative benefit of bevacizumab in older patients has not been widely studied and is of interest. Patients and methods This retrospective analysis used data from three first-line randomized controlled studies and one second-line randomized controlled study of bevacizumab plus chemotherapy in medically fit (Eastern Cooperative Oncology Group performance status 0 or 1) patients with mCRC. Overall survival (OS) and on-treatment progression-free survival (PFS) were assessed in patients aged
- Subjects :
- Oncology
Male
Cancer Research
genetic structures
Colorectal cancer
medicine.medical_treatment
Angiogenesis Inhibitors
Metastasis
Medicine & Public Health
Neoplasm Metastasis
Randomized Controlled Trials as Topic
Hematology
Metastatic colorectal cancer
Age Factors
Antibodies, Monoclonal
General Medicine
Middle Aged
Bevacizumab
Female
Colorectal Neoplasms
medicine.drug
Adult
medicine.medical_specialty
Randomization
Adolescent
Antibodies, Monoclonal, Humanized
Pooled analysis
Internal medicine
Internal Medicine
medicine
Older patients
Chemotherapy
Humans
Aged
Retrospective Studies
Original Paper
business.industry
Cancer
Retrospective cohort study
medicine.disease
eye diseases
digestive system diseases
Surgery
sense organs
business
Subjects
Details
- Language :
- English
- ISSN :
- 14321335 and 01715216
- Volume :
- 136
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer Research and Clinical Oncology
- Accession number :
- edsair.doi.dedup.....fa8a995fc0831ff73fee430a2cee8592