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Effect of neramexane on ethanol dependence and reinforcement
- Source :
- European Journal of Pharmacology. 503:95-98
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- It has been suggested that drugs modulating the glutamate/N-methyl-D-aspartate (NMDA) receptor system may be useful in the treatment of alcohol dependence. The effect of neramexane, a low-to-moderate affinity uncompetitive NMDA receptor antagonist, was examined on the development and expression of ethanol dependence (withdrawal-associated audiogenic seizures) and ethanol-induced conditioned place preference. Neramexane hydrochloride (3.5 mg/kg and higher) inhibited both the development and expression of ethanol dependence. Neramexane hydrochloride also inhibited the acquisition (1.75 mg/kg and higher) and expression (3.5 mg/kg and higher) of ethanol-induced place preference. Our data support therapeutic potential of neramexane as a treatment for alcohol abuse.
- Subjects :
- Male
Taurine
Hydrochloride
Acamprosate
Cyclopentanes
Pharmacology
Receptors, N-Methyl-D-Aspartate
chemistry.chemical_compound
Seizures
Animals
Rats, Wistar
Ethanol
Behavior, Animal
Alcohol dependence
Glutamate receptor
Antagonist
Central Nervous System Depressants
Neramexane
Conditioned place preference
Rats
Substance Withdrawal Syndrome
Alcoholism
chemistry
Conditioning, Operant
NMDA receptor
Reinforcement, Psychology
Alcohol Deterrents
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 503
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....fa809123b198df26077e728390d4a544