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An update of cancer mortality among the French cohort of uranium miners: Extended follow-up and new source of data for causes of death
- Source :
- European Journal of Epidemiology, European Journal of Epidemiology, 2004, 19 (2), pp.139-146. ⟨10.1023/B:EJEP.0000017824.38966.01⟩
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- The follow-up of the French cohort of uranium miners has been extended to 1994, and a new source of information for causes of death has been used. The paper presents the new results regarding the risk of death among the cohort, and analyses the impact of the methodological changes on these results. The extension of the follow-up results in a substantial increase in statistical power compared with previous analysis (+25% for person-years and +74% for the number of deaths). The use of the National Mortality Database as the principal source for causes of death allows to reduce the potential bias in the calculation of standardized mortality ratios (SMR). As a consequence, an excess risk of deaths from laryngeal cancer, suggested in the first analysis, is not confirmed. The analysis shows the existence of an excess risk of deaths from lung cancer among French uranium miners (85 observed deaths, SMR = 1.9, 95% confidence interval CI: 1.5-2.3), and an increase of this risk with cumulative exposure to radon (excess relative risk per 100 working level month = 0.6, 95% CI: 0.1-1.2). These results confirm the existence of a risk of death from lung cancer in a population chronically exposed to relatively low levels of radon.
- Subjects :
- Male
Lung Neoplasms
Neoplasms, Radiation-Induced
uranium mine
Epidemiology
[SDV]Life Sciences [q-bio]
low energy radiation
030218 nuclear medicine & medical imaging
Cohort Studies
0302 clinical medicine
data base
Neoplasms
Cause of Death
cancer mortality
Medicine
Poisson Distribution
Cause of death
education.field_of_study
Incidence
article
Absolute risk reduction
radon
Middle Aged
cohort analysis
3. Good health
Occupational Diseases
aged
030220 oncology & carcinogenesis
Cohort
Uranium
France
radiation dose
Risk assessment
Cohort study
Adult
medicine.medical_specialty
Population
Risk Assessment
Mining
03 medical and health sciences
Age Distribution
statistical analysis
Occupational Exposure
Confidence Intervals
follow up
larynx carcinoma
Humans
controlled study
human
education
Retrospective Studies
business.industry
Retrospective cohort study
major clinical study
Surgery
confidence interval
Radiation-Induced
Relative risk
lung carcinoma
business
Demography
Subjects
Details
- ISSN :
- 03932990
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- European Journal of Epidemiology
- Accession number :
- edsair.doi.dedup.....fa7a382573124fe30febc18938d205c6