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Uterine Tumors Resembling Ovarian Sex-Cord Tumors Have an Immunophenotype Consistent With True Sex-Cord Differentiation
- Source :
- The American Journal of Surgical Pathology. 22:1078-1082
- Publication Year :
- 1998
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1998.
-
Abstract
- Seven examples of Clement and Scully's type II uterine tumors resembling ovarian sex cord tumors were studied immunohistochemically with markers of sex cord, steroid cell differentiation (inhibin, O13, A103), or both, and were found to be immunoreactive for one or more of these markers in all cases. There was also constant immunoreactivity for vimentin and for hormone receptors and variable positivity for keratin, actin, and desmin. These findings provide strong evidence for the presence of true sex cord elements in these tumors, the derivation of which remains speculative.
- Subjects :
- Adult
endocrine system
Pathology
medicine.medical_specialty
endocrine system diseases
Cellular differentiation
Uterus
Biology
Endometrium
Desmin
Immunophenotyping
Pathology and Forensic Medicine
Stroma
medicine
Humans
Sex Cord-Gonadal Stromal Tumors
Vimentin
Aged
Endometrial stromal sarcoma
Middle Aged
medicine.disease
Actins
Neoplasm Proteins
medicine.anatomical_structure
In utero
Uterine Neoplasms
Keratins
Immunohistochemistry
Female
Surgery
Anatomy
Subjects
Details
- ISSN :
- 01475185
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- The American Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....fa606ebc719136164e758e4ad9c73876