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Mitigation of Radiation-induced Gastrointestinal System Injury using Resveratrol or Alpha-lipoic Acid: A Pilot Histopathological Study
- Source :
- Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 19:413-424
- Publication Year :
- 2020
- Publisher :
- Bentham Science Publishers Ltd., 2020.
-
Abstract
- Aim: In this study, we aimed to determine possible mitigation of radiationinduced toxicities in the duodenum, jejunum and colon using post-exposure treatment with resveratrol and alpha-lipoic acid. Background: After the bone marrow, gastrointestinal system toxicity is the second critical cause of death following whole-body exposure to radiation. Its side effects reduce the quality of life of patients who have undergone radiotherapy. Resveratrol has an antioxidant effect and stimulates DNA damage responses (DDRs). Alpha-lipoic acid neutralizes free radicals via the recycling of ascorbic acid and alpha-tocopherol. Objective: This study is a pilot investigation of the mitigation of enteritis using resveratrol and alpha-lipoic acid following histopathological study. Methods: 60 male mice were randomly assigned to six groups; control, resveratrol treatment, alpha-lipoic acid treatment, whole-body irradiation, irradiation plus resveratrol, and irradiation plus alpha-lipoic acid. The mice were irradiated with a single dose of 7 Gy from a cobalt-60 gamma-ray source. Treatment with resveratrol or alpha-lipoic acid started 24 h after irradiation and continued for 4 weeks. All mice were sacrificed after 30 days for histopathological evaluation of radiation-induced toxicities in the duodenum, jejunum and colon. Results and Conclusion: Exposure to radiation caused mild to severe damages to vessels, goblet cells and villous. It also led to significant infiltration of macrophages and leukocytes, especially in the colon. Both resveratrol and alpha-lipoic acid were able to mitigate morphological changes. However, they could not mitigate vascular injury. Conclusion: Resveratrol and alpha-lipoic acid could mitigate radiation-induced injuries in the small and large intestine. A comparison between these agents showed that resveratrol may be a more effective mitigator compared to alpha-lipoic acid.
- Subjects :
- Male
Antioxidant
Colon
Duodenum
Alpha-Lipoic Acid
medicine.medical_treatment
Immunology
Radiation-Protective Agents
Pharmacology
Resveratrol
Jejunum
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Animals
Immunology and Allergy
Large intestine
030304 developmental biology
0303 health sciences
Thioctic Acid
business.industry
General Medicine
Ascorbic acid
Radiation Injuries, Experimental
medicine.anatomical_structure
chemistry
Gamma Rays
030220 oncology & carcinogenesis
Toxicity
business
Whole-Body Irradiation
Subjects
Details
- ISSN :
- 18715230
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....fa5fa0f68c7889b1f928139b3f6a7641