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An overview on anti-tubulin agents for the treatment of lymphoma patients
- Source :
- Pharmacology & Therapeutics. 211:107552
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors and hematologic malignancies, due to the interference with microtubule dynamics. Since microtubules play crucial roles in the regulation of the mitotic spindles, the interference with their function usually leads to a block in cell division with arrest at the metaphase/anaphase junction of mitosis, followed to apoptosis. This explains the reason why tubulin-binding agents (TBAs) proved to be extremely active in patients with cancer. Several anti-tubulin agents are indicated in the treatment of patients with lymphomas both alone and in combination chemotherapy regimens. The article reviews the literature on classic and more recent anti-tubulin agents, providing an insight into their mechanisms of action and their use in the treatment of lymphoma.
- Subjects :
- 0301 basic medicine
Vinca alkaloids
Lymphoma
Mitosis
Antineoplastic Agents
Apoptosis
macromolecular substances
Microtubules
Antibody drug conjugates
Taxanes
03 medical and health sciences
0302 clinical medicine
Tubulin
Microtubule
medicine
Animals
Humans
Maytansine
Pharmacology (medical)
Metaphase
Anaphase
Pharmacology
biology
business.industry
Cancer
Combination chemotherapy
medicine.disease
Tubulin Modulators
030104 developmental biology
Epothilones
030220 oncology & carcinogenesis
biology.protein
Cancer research
Dolastatins
business
Subjects
Details
- ISSN :
- 01637258
- Volume :
- 211
- Database :
- OpenAIRE
- Journal :
- Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....fa5e655364840171aca57e47af81a946