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Nanohydroxyapatite-Mediated Imatinib Delivery for Specific Anticancer Applications
- Source :
- Molecules, Vol 25, Iss 4602, p 4602 (2020), Molecules, Volume 25, Issue 20
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- In the present study, a nanoapatite-mediated delivery system for imatinib has been proposed. Nanohydroxyapatite (nHAp) was obtained by co-precipitation method, and its physicochemical properties in combination with imatinib (IM) were studied by means of XRPD (X-ray Powder Diffraction), SEM-EDS (Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy), FT-IR (Fourier-Transform Infrared Spectroscopy), absorption spectroscopy as well as DLS (Dynamic Light Scattering) techniques. The obtained hydroxyapatite was defined as nanosized rod-shaped particles with high crystallinity. The amorphous imatinib was obtained by conversion of its crystalline form. The beneficial effects of amorphous pharmaceutical agents have been manifested in the higher dissolution rate in body fluids improving their bioavailability. Imatinib-to-hydroxyapatite interactions on the surface were confirmed by SEM images as well as absorption and FT-IR spectroscopy. The cytotoxicity of the system was tested on NI-1, L929, and D17 cell lines. The effectiveness of imatinib was not affected by nHAp modification. The calculated IC50 values for drug-modified nHAp were similar to those for the drug itself. However, higher cytotoxicity was observed at higher concentrations of imatinib, in comparison with the drug alone.
- Subjects :
- Absorption (pharmacology)
Absorption spectroscopy
anticancer targeted therapies
Cell Survival
Scanning electron microscope
Pharmaceutical Science
Infrared spectroscopy
Antineoplastic Agents
02 engineering and technology
Microscopy, Atomic Force
Article
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
Crystallinity
0302 clinical medicine
Dynamic light scattering
lcsh:Organic chemistry
Cell Line, Tumor
Spectroscopy, Fourier Transform Infrared
Drug Discovery
Humans
Physical and Theoretical Chemistry
Spectroscopy
Chemistry
Organic Chemistry
Spectrometry, X-Ray Emission
021001 nanoscience & nanotechnology
Dynamic Light Scattering
Bioavailability
Durapatite
imatinib
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
Imatinib Mesylate
Molecular Medicine
cytotoxicity
nanohydroxyapatite
0210 nano-technology
Nuclear chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 4602
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....fa57865afc2c4b9226897bc406c06cd6