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Anthracycline-based and gemcitabine-based chemotherapy in the adjuvant setting for stage I uterine leiomyosarcoma: a retrospective analysis at two reference centers
- Source :
- Clinical Sarcoma Research, Vol 10, Iss 1, Pp 1-6 (2020), Clinical Sarcoma Research
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Background Radically resected early uterine leiomyosarcoma (eULMS) is still marked by a poor prognosis. Adjuvant strategies investigated up to now have not been corroborated by controlled studies. We retrospectively reviewed the clinical outcome of eULMS patients treated with adjuvant anthracycline-based or gemcitabine-based chemotherapy at two Italian reference centers. Methods In this explorative, retrospective, cohort analysis, we included all the consecutive patients with radically resected eULMS treated at two centers between 1997 and 2017. Results A total of 109 consecutive patients were included. Sixty-six (60%) received an anthracycline-based regimen, whereas 43 (40%) received a gemcitabine-based regimen. Median disease-free survival (DFS) was 41.3 months with anthracycline-based regimens compared to 20.9 months with gemcitabine-based regimens (HR: 0.49; 95% CI: 0.30–0.80; P = 0.004). In the multivariable model, anthracycline-based regimens were independently associated with a better DFS. No difference in terms of overall survival was observed. Conclusions DFS was not the same by using an anthracycline-based or a gemcitabine-based adjuvant chemotherapy for patients with radically resected eULMS. The results of our study are in line with recent prospective controlled evidence in limb and superficial trunk soft tissue sarcomas. The role of anthracycline-based adjuvant chemotherapy should still be viewed as a research issue in eULMS.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Anthracycline
medicine.medical_treatment
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Surgical oncology
Internal medicine
Uterine leiomyosarcoma
Medicine
Chemotherapy
business.industry
Research
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Gemcitabine
Adjuvant chemotherapy
Regimen
030104 developmental biology
030220 oncology & carcinogenesis
business
Adjuvant
Cohort study
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20453329
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical Sarcoma Research
- Accession number :
- edsair.doi.dedup.....fa54916ff14465e018b01c7e40b8578e