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Rectal protection in prostate stereotactic radiotherapy: a retrospective exploratory analysis of two rectal displacement devices
- Source :
- Journal of Medical Radiation Sciences
- Publication Year :
- 2017
-
Abstract
- Introduction High rectal doses are associated with increased toxicity. A rectal displacement device (RDD) reduces rectal dose in prostate stereotactic body radiation therapy (SBRT). This study investigates any dosimetric difference between two methods of rectal displacement (Rectafix and SpaceOAR) for prostate SBRT. Methods Rectal dosimetry of 45 men who received SBRT within the PROMETHEUS trial was retrospectively examined, across two radiation therapy centres using the two RDD's. Men received a total dose (TD) of 19 or 20 Gy in two fractions followed by 46 Gy in 23 fractions. Centre 1 contributed 16 Rectafix and 10 SpaceOAR patients. Centre 2 contributed 19 Rectafix patients. Rectal dose volume histogram (DVH) data were recorded as a TD percentage at the following volume intervals; V1%, V2%, V5%, V10% and then 10% increments to V80%. As only one centre employed both RDD's, three sequential rectal dosimetry comparisons were performed; (1) centre 1 Rectafix versus centre 1 SpaceOAR; (2) centre 1 Rectafix versus centre 2 Rectafix and (3) centre 1+ centre 2 Rectafix versus centre 1 SpaceOAR. Results In comparison (1) Rectafix demonstrated lower mean doses at 9 out of 11 measured intervals (P = 0.0012). Comparison (2) demonstrated a moderate difference with centre 2 plans producing slightly lower rectal doses (P = 0.013). Comparison (3) further demonstrated that Rectafix returned lower mean doses than SpaceOAR (P < 0.001). Although all dose levels were in favour of Rectafix, in absolute terms differences were small (2.6–9.0%). Conclusions In well‐selected prostate SBRT patients, Rectafix and SpaceOAR RDD's provide approximately equivalent rectal sparing.
- Subjects :
- Male
medicine.medical_specialty
Dose-volume histogram
rectal displacement device
medicine.medical_treatment
Rectum
rectafix
030218 nuclear medicine & medical imaging
Stereotactic radiotherapy
Stereotaxic Techniques
03 medical and health sciences
0302 clinical medicine
Prostate
medicine
Dosimetry
Humans
Radiology, Nuclear Medicine and imaging
Radiation Injuries
Radiological and Ultrasound Technology
Radiotherapy
business.industry
Prostatic Neoplasms
Radiotherapy Dosage
Exploratory analysis
Original Articles
Surgery
Radiation therapy
medicine.anatomical_structure
stereotactic body radiotherapy
030220 oncology & carcinogenesis
Stereotaxic technique
Original Article
spaceOAR
business
Nuclear medicine
Prostatic neoplasm
Subjects
Details
- ISSN :
- 20513909
- Volume :
- 64
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of medical radiation sciences
- Accession number :
- edsair.doi.dedup.....fa4fecd80f0673d674a383e2c48a99d7