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Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer
- Source :
- Exp Dermatol
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The epidermis and skin appendages are maintained by their resident epithelial stem cells, which undergo long-term self-renewal and multilineage differentiation. Upon injury, stem cells are activated to mediate re-epithelialization and restore tissue function. During this process, they often mount lineage plasticity and expand their fates in response to damage signals. Stem cell function is tightly controlled by transcription machineries and signalling transductions, many of which derail in degenerative, inflammatory and malignant dermatologic diseases. Here, by describing both well-characterized and newly emerged pathways, we discuss the transcriptional and signalling mechanisms governing skin epithelial homeostasis, wound repair and squamous cancer. Throughout, we highlight common themes underscoring epithelial stem cell plasticity and tissue-level crosstalk in the context of skin physiology and pathology.
- Subjects :
- 0301 basic medicine
Skin Neoplasms
Skin physiology
Dermatology
Biology
Biochemistry
Article
Mice
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Transcription (biology)
Animals
Homeostasis
Humans
Molecular Biology
Transcription factor
Skin
Wound Healing
Stem Cells
Cell Differentiation
Epithelial Cells
Cell biology
Epithelial homeostasis
Crosstalk (biology)
030104 developmental biology
Signalling
Cellular Microenvironment
Stem cell
Hair Follicle
Signal Transduction
Subjects
Details
- ISSN :
- 16000625 and 09066705
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Experimental Dermatology
- Accession number :
- edsair.doi.dedup.....fa4711c85408e4ec8eec51bef7d2e7fc