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Presence of varices in patients after hepatitis C virus eradication predicts deterioration in the FIB‐4 index
Presence of varices in patients after hepatitis C virus eradication predicts deterioration in the FIB‐4 index
- Source :
- Hepatology Research. 49:473-478
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Aims The liver function of patients with hepatitis C virus (HCV) infection who obtained sustained virologic response (SVR) has been known to improve after HCV eradication. However, a predictor of liver function after SVR has not been definitively identified. The aim of this retrospective study was to identify a predictor of deteriorated liver function and Fibrosis-4 (FIB-4) index after SVR was achieved by direct-acting antiviral (DAA) treatment. Methods This study retrospectively enrolled 248 patients who obtained SVR by DAA treatment. None of the patients developed hepatocellular carcinoma during this study. Liver function was assessed at the end of treatment (EOT) and at 24, 48, 72, and 96 weeks after EOT. Results At 96 weeks after EOT, the serum aspartate aminotransferase and alanine aminotransferase levels were significantly decreased from those at EOT. The platelet count was significantly increased from 14.9 × 104 /μL at EOT to 17.1 × 104 /μL at 96 weeks after EOT. Ten patients showed an increased FIB-4 (>1.00) index. Multivariate analysis with 171 patients who underwent endoscopic assessment revealed that the presence of varices was an independent predictor of deterioration in the FIB-4 index (odds ratio, 5.56; P = 0.041). Conclusion Most of the study patients who obtained SVR showed improved liver function after EOT. Patients without increasing platelet counts after SVR due to DAA therapy should be evaluated for complications induced by portal hypertension.
- Subjects :
- medicine.medical_specialty
Hepatology
business.industry
Hepatitis C virus
virus diseases
Retrospective cohort study
Odds ratio
Fib 4 index
medicine.disease_cause
medicine.disease
Gastroenterology
digestive system diseases
03 medical and health sciences
0302 clinical medicine
Infectious Diseases
030220 oncology & carcinogenesis
Internal medicine
Hepatocellular carcinoma
medicine
Portal hypertension
030211 gastroenterology & hepatology
Liver function
Varices
business
Subjects
Details
- ISSN :
- 1872034X and 13866346
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Hepatology Research
- Accession number :
- edsair.doi.dedup.....fa414bbfe28ef738897546d5a9694aaa
- Full Text :
- https://doi.org/10.1111/hepr.13296